Detalhe da pesquisa
1.
Rapid human genomic DNA cloning into mouse artificial chromosome via direct chromosome transfer from human iPSC and CRISPR/Cas9-mediated translocation.
Nucleic Acids Res
; 52(3): 1498-1511, 2024 Feb 09.
Artigo
Inglês
| MEDLINE | ID: mdl-38180813
2.
A transchromosomic rat model with human chromosome 21 shows robust Down syndrome features.
Am J Hum Genet
; 109(2): 328-344, 2022 02 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35077668
3.
Metabolic Disposition of Triazolam and Clobazam in Humanized CYP3A Mice with a Double-Knockout Background of Mouse Cyp2c and Cyp3a Genes.
Drug Metab Dispos
; 51(2): 174-182, 2023 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36379710
4.
Influence of MDR1 gene polymorphism (2677G>T) on expression and function of P-glycoprotein at the blood-brain barrier: utilizing novel P-glycoprotein humanized mice with mutation.
Pharmacogenet Genomics
; 32(8): 288-292, 2022 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35997049
5.
Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation.
Proc Natl Acad Sci U S A
; 116(33): 16404-16409, 2019 08 13.
Artigo
Inglês
| MEDLINE | ID: mdl-31358627
6.
Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.
Proc Natl Acad Sci U S A
; 116(8): 3072-3081, 2019 02 19.
Artigo
Inglês
| MEDLINE | ID: mdl-30718425
7.
Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome.
BMC Biotechnol
; 20(1): 44, 2020 08 20.
Artigo
Inglês
| MEDLINE | ID: mdl-32819341
8.
Generation of a novel isogenic trisomy panel in human embryonic stem cells via microcell-mediated chromosome transfer.
Biochem Biophys Res Commun
; 508(2): 603-607, 2019 01 08.
Artigo
Inglês
| MEDLINE | ID: mdl-30509488
9.
Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans.
Drug Metab Dispos
; 46(11): 1756-1766, 2018 11.
Artigo
Inglês
| MEDLINE | ID: mdl-29777024
10.
Mouse embryonic stem cells with a multi-integrase mouse artificial chromosome for transchromosomic mouse generation.
Transgenic Res
; 24(4): 717-27, 2015 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-26055730
11.
A novel transchromosomic system: stable maintenance of an engineered Mb-sized human genomic fragment translocated to a mouse chromosome terminal region.
Transgenic Res
; 23(3): 441-53, 2014 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-24488595
12.
Characterization of immortalized ovarian epithelial cells with BRCA1/2 mutation.
Hum Cell
; 2024 Apr 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38615309
13.
Highly stable maintenance of a mouse artificial chromosome in human cells and mice.
Biochem Biophys Res Commun
; 442(1-2): 44-50, 2013 Dec 06.
Artigo
Inglês
| MEDLINE | ID: mdl-24216103
14.
Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model.
Sci Rep
; 13(1): 4360, 2023 03 16.
Artigo
Inglês
| MEDLINE | ID: mdl-36928364
15.
Phenotypic features of dystrophin gene knockout pigs harboring a human artificial chromosome containing the entire dystrophin gene.
Mol Ther Nucleic Acids
; 33: 444-453, 2023 Sep 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37588685
16.
Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans-chromosomic mouse line expressing human UGT2 enzymes.
Pharmacol Res Perspect
; 10(6): e01030, 2022 12.
Artigo
Inglês
| MEDLINE | ID: mdl-36424908
17.
Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci.
Nat Commun
; 13(1): 1841, 2022 04 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35383174
18.
Complete genetic correction of ips cells from Duchenne muscular dystrophy.
Mol Ther
; 18(2): 386-93, 2010 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-19997091
19.
Blastocyst complementation using Prdm14-deficient rats enables efficient germline transmission and generation of functional mouse spermatids in rats.
Nat Commun
; 12(1): 1328, 2021 02 26.
Artigo
Inglês
| MEDLINE | ID: mdl-33637711
20.
Construction of stable mouse artificial chromosome from native mouse chromosome 10 for generation of transchromosomic mice.
Sci Rep
; 11(1): 20050, 2021 10 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34625612